The plague is actually a specific chain of virus called Yersinia pestis. The reason we call massive virus spreading plagues is because that term grew so famous during the Black Death. The Black Death was actually a strain of the Plague virus called the Bubonic Plague. But you didn’t come here just for that, you wanted the biggest EPIDEMICS in history so here they are.
7) The Asian Flu
This virus outbreak has been speculated to have originally come from a change in the DNA of some wild ducks in Asia. The flu lasted for two years originating in Asia 1957-58. It killed around 2 million people. This is a pretty low death toll compared to the other plagues on this list!
6) The Antonine Plague